Summary of P2RY2

Uridine and adensoine nucleotides activate this receptor. This receptor, found on many cell types, is activated by ATP and UTP and is reported to be overexpressed on some cancer cell types. It is involved in many cellular functions, such as proliferation, apoptosis and inflammation.

P2Y2 nucleotide receptor (P2Y2R) is activated with equal potency by adenosine triphosphate (ATP) and uridine 5'-triphosphate (UTP) (R).

Uridine activates the P2Y2 receptor, which helps with neurite outgrowth (R).  This receptor potentiates the effects of neurotrophins (such as NGF) in neuronal development and regeneration.

P2Y2 receptors are required for enhanced neuronal differentiation and increase growth-associated protein-43 (GAP-43), a marker for axonal growth (R).

The P2Y2 receptor is believed to play an important role in neuroprotection under inflammatory conditions.  The receptors are increased under inflammatory conditions (IL-1b) for this reason (RR2).


The Function of P2RY2

Receptor for ATP and UTP coupled to G-proteins that activate a phosphatidylinositol-calcium second messenger system. The affinity range is UTP = ATP > ATP-gamma-S >> 2-methylthio-ATP = ADP.

Protein names

Recommended name:

P2Y purinoceptor 2

Short name:


Alternative name(s):

ATP receptor
P2U purinoceptor 1
P2U receptor 1
Purinergic receptor

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Top Gene-Substance Interactions

P2RY2 Interacts with These Diseases


Substances That Increase P2RY2

Substances That Decrease P2RY2

Advanced Summary

Conditions with Increased Gene Activity

Conditions with Decreased Gene Activity