Summary

NR3C1 (nuclear receptor subfamily 3 group C member 1) encodes for glucocorticoid receptor. It is involved in inflammatory responses, cellular proliferation, and differentiation in target tissues (R). 

Glucocorticoid resistance can cause hypoglycemia, hypertension,fatigue, and anxiety (R). 


Function

Isoform Alpha-D3: Has lowest transcriptional activation activity of all isoforms created by alternative initiation (PubMed:15866175, PubMed:23820903). Has transcriptional repression activity (PubMed:23303127).

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