NR3C1 (nuclear receptor subfamily 3 group C member 1) encodes for glucocorticoid receptor. It is involved in inflammatory responses, cellular proliferation, and differentiation in target tissues (R). 

Glucocorticoid resistance can cause hypoglycemia, hypertension,fatigue, and anxiety (R). 


Isoform Alpha-D3: Has lowest transcriptional activation activity of all isoforms created by alternative initiation (PubMed:15866175, PubMed:23820903). Has transcriptional repression activity (PubMed:23303127).

Protein names

Recommended name:

Glucocorticoid receptor

Short name:


Alternative name(s):

Nuclear receptor subfamily 3 group C member 1

Get a Grip on Your Health. Use SelfDecode to Interpret your Genome Today! GET INSTANT ACCESS

Top Gene-Substance Interactions

Gene Interacts with Diseases

All Ways to Increase Gene

All Ways to Decrease Gene

Advanced Summary

Conditions with Increased Gene Activity

Conditions with Decreased Gene Activity