Summary of NR3C1

NR3C1 (nuclear receptor subfamily 3 group C member 1) encodes for glucocorticoid receptor. It is involved in inflammatory responses, cellular proliferation, and differentiation in target tissues (R). 

Glucocorticoid resistance can cause hypoglycemia, hypertension,fatigue, and anxiety (R). 

The Function of NR3C1

Isoform Alpha-D3: Has lowest transcriptional activation activity of all isoforms created by alternative initiation (PubMed:15866175, PubMed:23820903). Has transcriptional repression activity (PubMed:23303127).

Protein names

Recommended name:

Glucocorticoid receptor

Short name:


Alternative name(s):

Nuclear receptor subfamily 3 group C member 1

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Top Gene-Substance Interactions

NR3C1 Interacts with These Diseases

Substances That Increase NR3C1

Substances That Decrease NR3C1

Advanced Summary

Conditions with Increased Gene Activity

Conditions with Decreased Gene Activity