The Function of NR1H4

Isoform 4: Promotes transcriptional activation of target genes ABCB11/BSEP (inducible by unconjugated CDCA, ACA and DCA), NR0B2/SHP (inducible by unconjugated CDCA, ACA and DCA), SLC51B/OSTB (inducible by unconjugated CDCA and DCA) and FABP6/IBAP; most efficient isoform compared to isoforms 1 to 3; not inducible by taurine- and glycine-amidated CDCA.

Protein names

Recommended name:

Bile acid receptor

Alternative name(s):

Farnesoid X-activated receptor
Farnesol receptor HRR-1
Nuclear receptor subfamily 1 group H member 4
Retinoid X receptor-interacting protein 14
RXR-interacting protein 14

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Top Gene-Substance Interactions

NR1H4 Interacts with These Diseases

Substances That Increase NR1H4

Substances That Decrease NR1H4

Conditions with Increased Gene Activity

Conditions with Decreased Gene Activity