Summary of NR1H3

This gene encodes a protein that is one of the key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation (R). 

The Function of NR1H3

Nuclear receptor. Interaction with RXR shifts RXR from its role as a silent DNA-binding partner to an active ligand-binding subunit in mediating retinoid responses through target genes defined by LXRES. LXRES are DR4-type response elements characterized by direct repeats of two similar hexanuclotide half-sites spaced by four nucleotides. Plays an important role in the regulation of cholesterol homeostasis, regulating cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8. Interplays functionally with RORA for the regulation of genes involved in liver metabolism (By similarity). Exhibits a ligand-dependent transcriptional activation activity (PubMed:25661920).

Protein names

Recommended name:

Oxysterols receptor LXR-alpha

Alternative name(s):

Liver X receptor alpha
Nuclear receptor subfamily 1 group H member 3

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Top Gene-Substance Interactions

NR1H3 Interacts with These Diseases

Substances That Increase NR1H3

Substances That Decrease NR1H3

Conditions with Increased Gene Activity

Conditions with Decreased Gene Activity