The Function of NOX4

Isoform 4: Involved in redox signaling in vascular cells. Constitutively and NADPH-dependently generates reactive oxygen species (ROS). Modulates the nuclear activation of ERK1/2 and the ELK1 transcription factor, and is capable of inducing nuclear DNA damage. Displays an increased activity relative to isoform 1.

Protein names

Recommended name:

NADPH oxidase 4

Short name:


Alternative name(s):

Kidney oxidase-1
Kidney superoxide-producing NADPH oxidase
Renal NAD(P

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Top Gene-Substance Interactions

NOX4 Interacts with These Diseases

Substances That Increase NOX4

Substances That Decrease NOX4

Conditions with Increased Gene Activity

Conditions with Decreased Gene Activity