Summary

NOS2 encodes Inducible NOS (iNOS) in the immune system and cardiovascular system. It helps in immune defense against pathogens by producing nitric oxide. a free radical.

NOS2 helps neurotransmission and has antimicrobial and antitumor activities (R).

NOS2 contributes to inflammation, by enhancing the synthesis of inflammatory cytokines such as IL6 and IL8. It's also induced by inflammation.

Nitric oxide lowers blood pressure.

This gene is associated with hypertension and susceptibility to malaria.


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