Summary

NGFR (nerve growth factor receptor) encodes a protein that has a nerve growth factor binding domain. It plays a role in the regulation of the translocation of GLUT4  in response to insulin, so it helps regulate insulin-dependent glucose uptake. It mediates both cell survival and cell death of neural cells (R). 


Function

Plays a role in the regulation of the translocation of GLUT4 to the cell surface in adipocytes and skeletal muscle cells in response to insulin, probably by regulating RAB31 activity, and thereby contributes to the regulation of insulin-dependent glucose uptake (By similarity). Low affinity receptor which can bind to NGF, BDNF, NT-3, and NT-4. Can mediate cell survival as well as cell death of neural cells. Necessary for the circadian oscillation of the clock genes ARNTL/BMAL1, PER1, PER2 and NR1D1 in the suprachiasmatic nucleus (SCN) of the brain and in liver and of the genes involved in glucose and lipid metabolism in the liver.

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