Summary of NFKBIA

The gene codes for a protein, NFKB inhibitor alpha. Mutations may cause ectodermal dysplasia anhidrotic with T-cell immunodeficiency autosomal dominant disease [R].

The Function of NFKBIA

Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals. On cellular stimulation by immune and proinflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to translocate to the nucleus and activate transcription.

Protein names

Recommended name:

NF-kappa-B inhibitor alpha

Alternative name(s):

Major histocompatibility complex enhancer-binding protein MAD3

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Top Gene-Substance Interactions

NFKBIA Interacts with These Diseases

Substances That Increase NFKBIA

Substances That Decrease NFKBIA

Advanced Summary

Conditions with Increased Gene Activity

Conditions with Decreased Gene Activity