Summary of NFE2L2

Nuclear factor (erythroid-derived 2)-like 2, also known as NFE2L2 or Nrf2, is a protein (transcription factor). Nrf2 increases the expression of antioxidant proteins that protect against oxidative damage triggered by injury and inflammation.

Substances that stimulate the Nrf2 pathway are being studied for the treatment of diseases that are caused by oxidative stress.

It responds to injury and inflammation [R].

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The Function of NFE2L2

Transcription activator that binds to antioxidant response (ARE) elements in the promoter regions of target genes. Important for the coordinated up-regulation of genes in response to oxidative stress. May be involved in the transcriptional activation of genes of the beta-globin cluster by mediating enhancer activity of hypersensitive site 2 of the beta-globin locus control region.

Protein names

Recommended name:

Nuclear factor erythroid 2-related factor 2

Short name:


Alternative name(s):

NF-E2-related factor 2
NFE2-related factor 2
Nuclear factor, erythroid derived 2, like 2

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Top Gene-Substance Interactions

NFE2L2 Interacts with These Diseases


Substances That Increase NFE2L2

Substances That Decrease NFE2L2

Advanced Summary

Conditions with Increased Gene Activity

Conditions with Decreased Gene Activity