Summary of NAMPT

Increased levels of visfatin/NAMPT are associated with the following medical conditions: atherosclerosis, metabolic syndrome, renal insufficiency, diabetes, obesity, and inflammation.

The Function of NAMPT

Catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian NAD biosynthesis pathway. The secreted form behaves both as a cytokine with immunomodulating properties and an adipokine with anti-diabetic properties, it has no enzymatic activity, partly because of lack of activation by ATP, which has a low level in extracellular space and plasma. Plays a role in the modulation of circadian clock function. NAMPT-dependent oscillatory production of NAD regulates oscillation of clock target gene expression by releasing the core clock component: CLOCK-ARNTL/BMAL1 heterodimer from NAD-dependent SIRT1-mediated suppression.

Protein names

Recommended name:

Nicotinamide phosphoribosyltransferase

Alternative name(s):

Pre-B-cell colony-enhancing factor 1
Pre-B cell-enhancing factor

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Top Gene-Substance Interactions

NAMPT Interacts with These Diseases

Substances That Increase NAMPT

Substances That Decrease NAMPT

Advanced Summary

Conditions with Increased Gene Activity

Conditions with Decreased Gene Activity