Summary of MUTYH

The gene codes for a protein, mutY DNA glycosylase. Mutations cause a higher susceptibility to colon and stomach cancer [R].

The Function of MUTYH

Involved in oxidative DNA damage repair. Initiates repair of A*oxoG to C*G by removing the inappropriately paired adenine base from the DNA backbone. Possesses both adenine and 2-OH-A DNA glycosylase activities.

Protein names

Recommended name:

Adenine DNA glycosylase

Alternative name(s):

MutY homolog

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Top Gene-Substance Interactions

MUTYH Interacts with These Diseases

Substances That Increase MUTYH

Substances That Decrease MUTYH

Advanced Summary

Conditions with Increased Gene Activity

Conditions with Decreased Gene Activity