Summary

MTR helps convert homocysteine to methionine.

MTR (5-methyltetrahydrofolate-homocysteine methyltransferase) encodes methionine synthase, an enzyme that plays a role in processing amino acids (building blocks of proteins). The body uses methionine to make proteins and other important compounds (R). 

One specific version of this gene is associated with birth defects and the possibility of the child having Down's syndrome (R). 


Function

Catalyzes the transfer of a methyl group from methyl-cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.

Protein names

Recommended name:

Methionine synthase

Short name:

MS

Alternative name(s):

5-methyltetrahydrofolate--homocysteine methyltransferase
Vitamin-B12 dependent methionine synthase

Get a Grip on Your Health. Use SelfDecode to Interpret your Genome Today! GET INSTANT ACCESS

Top Gene-Substance Interactions

Gene Interacts with Diseases

All Ways to Increase Gene

All Ways to Decrease Gene

Advanced Summary

Conditions with Increased Gene Activity

Conditions with Decreased Gene Activity

Technical