Summary of MTHFR

The MTHFR gene codes for an enzyme known as methylenetetrahydrofolate reductase or MTHFR. This enzyme is very important for the production of DNA and methylation pathways that are essential for all bodily functions [R]. Genetic variations in the MTHFR gene results in reduced activity of the enzyme produced and have been associated with a series of diseases and conditions, including cardiovascular disorders, neurological defects, some forms of cancer, psychiatric disorders, diabetes, and pregnancy complications [R, R2].

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The Function of MTHFR

Catalyzes the conversion of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, a co-substrate for homocysteine remethylation to methionine.

Protein names

Recommended name:

Methylenetetrahydrofolate reductase

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Top Gene-Substance Interactions

MTHFR Interacts with These Diseases


Substances That Increase MTHFR

Substances That Decrease MTHFR

Advanced Summary

Conditions with Increased Gene Activity

Conditions with Decreased Gene Activity