Summary of MTDH

MTDH (Metadherin) encodes proteins that are involved in the formation of new blood vessels (R). 

The protein helps in progression and development of cancer by promoting angiogenesis (R). 


The Function of MTDH

Downregulates SLC1A2/EAAT2 promoter activity when expressed ectopically. Activates the nuclear factor kappa-B (NF-kappa-B) transcription factor. Promotes anchorage-independent growth of immortalized melanocytes and astrocytes which is a key component in tumor cell expansion. Promotes lung metastasis and also has an effect on bone and brain metastasis, possibly by enhancing the seeding of tumor cells to the target organ endothelium. Induces chemoresistance.

Protein names

Recommended name:

Protein LYRIC

Short name:

AEG-1

Alternative name(s):

3D3/LYRIC
Astrocyte elevated gene-1 protein
Lysine-rich CEACAM1 co-isolated protein
Metadherin
Metastasis adhesion protein

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Top Gene-Substance Interactions

MTDH Interacts with These Diseases

Substances That Increase MTDH

Substances That Decrease MTDH

Advanced Summary

Conditions with Increased Gene Activity

Conditions with Decreased Gene Activity

Technical