Summary of MTAP

The gene codes for an enzyme, methylthioadenosine phosphorylase. It is not found very often in many cancers because this gene and the tumor suppressor p16 gene are co-deleted [R].


The Function of MTAP

Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.

Protein names

Recommended name:

S-methyl-5'-thioadenosine phosphorylase

Short name:

MTAP

Alternative name(s):

5'-methylthioadenosine phosphorylase
MTA phosphorylase
MTAPase

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Top Gene-Substance Interactions

MTAP Interacts with These Diseases

Substances That Increase MTAP

Substances That Decrease MTAP

Advanced Summary

Conditions with Increased Gene Activity

Conditions with Decreased Gene Activity

Technical