Summary of MME

This gene encodes for an antigen that is an important cell surface marker in the diagnosis of human acute lymphocytic leukemia [R]

 

 


The Function of MME

Thermolysin-like specificity, but is almost confined on acting on polypeptides of up to 30 amino acids (PubMed:15283675, PubMed:8168535). Biologically important in the destruction of opioid peptides such as Met- and Leu-enkephalins by cleavage of a Gly-Phe bond (PubMed:17101991). Able to cleave angiotensin-1, angiotensin-2 and angiotensin 1-9 (PubMed:15283675). Involved in the degradation of atrial natriuretic factor (ANF) (PubMed:2531377, PubMed:2972276). Displays UV-inducible elastase activity toward skin preelastic and elastic fibers (PubMed:20876573).

Protein names

Recommended name:

Neprilysin

Short name:

NEP

Alternative name(s):

Atriopeptidase
Common acute lymphocytic leukemia antigen
CALLA
Enkephalinase
Neutral endopeptidase 24.11
Neutral endopeptidase
Skin fibroblast elastase
SFE
CD antigen CD10

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Top Gene-Substance Interactions

MME Interacts with These Diseases

Substances That Increase MME

Substances That Decrease MME

Advanced Summary

Conditions with Increased Gene Activity

Conditions with Decreased Gene Activity

Technical