The Function of MKI67

Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). Associates with the surface of the mitotic chromosome, the perichromosomal layer, and covers a substantial fraction of the chromosome surface (PubMed:27362226). Prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization (PubMed:24867636). It is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in maintaining mitotic chromosomes dispersed.

Protein names

Recommended name:

Proliferation marker protein Ki-67

Alternative name(s):

Antigen identified by monoclonal antibody Ki-67
Antigen KI-67
Antigen Ki67

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Top Gene-Substance Interactions

MKI67 Interacts with These Diseases

Substances That Increase MKI67

Substances That Decrease MKI67

Conditions with Increased Gene Activity

Conditions with Decreased Gene Activity

Technical