Summary of MECP2

The MECP2 gene encodes a protein called MeCP2. The exact function of this protein is unknown, but it appears to help regulate gene activity and helps neurons function (R). 

Mutations of this gene can cause brain disorders (R). 


The Function of MECP2

Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Mediates transcriptional repression through interaction with histone deacetylase and the corepressor SIN3A. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC).

Protein names

Recommended name:

Methyl-CpG-binding protein 2

Alternative name(s):

MeCp-2 protein
MeCp2

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Top Gene-Substance Interactions

MECP2 Interacts with These Diseases

Substances That Increase MECP2

Substances That Decrease MECP2

Conditions with Increased Gene Activity

Conditions with Decreased Gene Activity

Technical