The Function of MDM4

Inhibits p53/TP53- and TP73/p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Inhibits degradation of MDM2. Can reverse MDM2-targeted degradation of TP53 while maintaining suppression of TP53 transactivation and apoptotic functions.

Protein names

Recommended name:

Protein Mdm4

Alternative name(s):

Double minute 4 protein
Mdm2-like p53-binding protein
Protein Mdmx
p53-binding protein Mdm4

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Top Gene-Substance Interactions

MDM4 Interacts with These Diseases

Substances That Increase MDM4

Substances That Decrease MDM4

Conditions with Increased Gene Activity

Conditions with Decreased Gene Activity