Summary

MAPT codes for a protein named tau which is involved in assembling and stabilizing microtubules. Microtubules help maintain cell shape, cell division, transportation of materials within cells (R). 

Mutations in the MAPT gene can cause dementia and other brain disorders (R). 


Function

Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.

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