Summary of MAPK1

The gene codes for a protein, mitogen-activated protein kinase 1. It performs mechanistically distinct functions [R].


The Function of MAPK1

Acts as a transcriptional repressor. Binds to a [GC]AAA[GC] consensus sequence. Repress the expression of interferon gamma-induced genes. Seems to bind to the promoter of CCL5, DMP1, IFIH1, IFITM1, IRF7, IRF9, LAMP3, OAS1, OAS2, OAS3 and STAT1. Transcriptional activity is independent of kinase activity.

Protein names

Recommended name:

Mitogen-activated protein kinase 1

Short name:

ERT1

Alternative name(s):

MAP kinase 1
MAPK 1
Extracellular signal-regulated kinase 2
ERK-2
MAP kinase isoform p42
p42-MAPK
Mitogen-activated protein kinase 2
MAP kinase 2
MAPK 2

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Top Gene-Substance Interactions

MAPK1 Interacts with These Diseases

Substances That Increase MAPK1

Substances That Decrease MAPK1

Conditions with Increased Gene Activity

Conditions with Decreased Gene Activity

Technical