Summary of MAP3K3

The gene codes for a protein, mitogen-activated protein kinase kinase kinase 3. The protein regulates the stress-activated protein kinase (SAPK) and extracellular signal-regulated protein kinase (ERK) pathways by activating SEK and MEK1/2 respectively. It does not regulate the p38 pathway [R].


The Function of MAP3K3

Component of a protein kinase signal transduction cascade. Mediates activation of the NF-kappa-B, AP1 and DDIT3 transcriptional regulators.

Protein names

Recommended name:

Mitogen-activated protein kinase kinase kinase 3

Short name:

MEKK 3

Alternative name(s):

MAPK/ERK kinase kinase 3
MEK kinase 3

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Top Gene-Substance Interactions

MAP3K3 Interacts with These Diseases

Substances That Increase MAP3K3

Substances That Decrease MAP3K3

Conditions with Increased Gene Activity

Conditions with Decreased Gene Activity

Technical