Summary

Monoamine oxidase A (MAO-A) is an enzyme in the brain that breaks down neurotransmitters such as noradrenaline, adrenaline, serotonin, and dopamine. (R)

If we have high levels of this enzyme, it means we'll have fewer neurotransmitters. If we have low levels of this enzyme, we'll have more  neurotransmitters. MAO-A is not something we want to be too high or too low because in both situations it will cause different negative effects.


Function

Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOA preferentially oxidizes biogenic amines such as 5-hydroxytryptamine (5-HT), norepinephrine and epinephrine.

Protein names

Recommended name:

Amine oxidase [flavin-containing] A

Short name:

MAO-A

Alternative name(s):

Monoamine oxidase type A

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