Summary of LXR
Liver X receptors (LXRs) are important regulators of cholesterol, fatty acid, and glucose homeostasis. LXR helps metabolize fat, decrease inflammation (especially in gut), fight infections, improve glucose tolerance and detox. LXRs may help combat:
- Heart disease,
- Fatty liver,
- Gut inflammation,
- Prostate and breast cancer (R).
Gene is also known as NR1H2.
Top Gene-Substance Interactions
Read: About Liver X Receptors (LXR) And Natural Activators Top Ways to Increase LXR:
Dietary fix: Limit Omega-6s, because PUFAs and arachidonic acid are antagonists to LXR, which means they block LXR (R).
- Taurine -powder (R), - also inhibits,
- Sterols/Stanols (R),
- Chrysin (R),
- Sitosterol (R),
- Cineole (in essential oils like eucalyptus, peppermint, lavender, sage, rosemary - these oils are Generally Recognized As Safe for consumption (GRAS)) (R),
- Cyanidin (common in fruits and veggies) (R),
- Diterpenes (steviol-Stevia, Forskolin ) (R),
What Inhibits LXR:
Substances That Increase LXR
Substances That Decrease LXR
Low LXR activity is thought to be a cause of atherosclerosis. Mice without LXR are healthy when fed with a low-cholesterol diet. However, they develop enlarged fatty livers, degeneration of liver cells, high cholesterol levels in liver, and impaired liver function when fed a high-cholesterol diet.
LXRs also regulate lipid homeostasis in the brain. Mice without LXR develop neurodegenerative changes in brain tissue. LXR activators are effective for treatment in mouse models of atherosclerosis, diabetes, inflammation, and Alzheimer's disease.
In mice, LXR can help prevent the amyloid beta formation, which causes Alzheimers (R). LXR activators lower cholesterol level in blood and liver. They improve glucose tolerance in mice by decreasing insulin resistance.
LXR activators were also shown to suppress the proliferation of prostate cancer and breast cancer cells as well as delay progression of prostate cancer. (Ref) LXR decreases inflammation by inhibiting Nf-kB (R). LXR represses a set of inflammatory genes after activation by bacterial components or cytokines (R).
LXR increases xenobiotic transport proteins, such as MDR1 (ABCB1) and MRP2 (ABCC2) (R). Less LXR is thought to play a causal role in Ulcerative Colitis (R). Loss of LXR function compromised innate immunity in an animal model, which shows the importance of LXR for a normal functioning immune system (R).
LXR plays an anti-microbial role and protects against Tuberculosis (R). LXR helps the secretion of insulin , which helps combat diabetes (R). LXR inhibits the production of the precursor for thyroid hormones , TRH (R).