The Function of LRRFIP1

Transcriptional repressor which preferentially binds to the GC-rich consensus sequence (5'-AGCCCCCGGCG-3') and may regulate expression of TNF, EGFR and PDGFA. May control smooth muscle cells proliferation following artery injury through PDGFA repression. May also bind double-stranded RNA. Positively regulates Toll-like receptor (TLR) signaling in response to agonist probably by competing with the negative FLII regulator for MYD88-binding.

Protein names

Recommended name:

Leucine-rich repeat flightless-interacting protein 1

Alternative name(s):

LRR FLII-interacting protein 1
GC-binding factor 2
TAR RNA-interacting protein

Get a Grip on Your Health. Use SelfDecode to Interpret your Genome Today! GET INSTANT ACCESS

Top Gene-Substance Interactions

LRRFIP1 Interacts with These Diseases

Substances That Increase LRRFIP1

Substances That Decrease LRRFIP1

Conditions with Increased Gene Activity

Conditions with Decreased Gene Activity