Summary of LRAT

The gene codes for a protein, lecithin retinol acyltransferase (phosphatidylcholine--retinol O-acyltransferase). It speeds up a reaction in vitamin A metabolism in the visual system. Mutations are linked to early-onset severe retinal dystrophy and Leber congenital amaurosis 14 [R].


The Function of LRAT

Transfers the acyl group from the sn-1 position of phosphatidylcholine to all-trans retinol, producing all-trans retinyl esters. Retinyl esters are storage forms of vitamin A. LRAT plays a critical role in vision. It provides the all-trans retinyl ester substrates for the isomerohydrolase which processes the esters into 11-cis-retinol in the retinal pigment epithelium; due to a membrane-associated alcohol dehydrogenase, 11 cis-retinol is oxidized and converted into 11-cis-retinaldehyde which is the chromophore for rhodopsin and the cone photopigments.

Protein names

Recommended name:

Lecithin retinol acyltransferase

Alternative name(s):

Phosphatidylcholine--retinol O-acyltransferase

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Top Gene-Substance Interactions

LRAT Interacts with These Diseases

Substances That Increase LRAT

Substances That Decrease LRAT

Advanced Summary

Conditions with Increased Gene Activity

Conditions with Decreased Gene Activity

Technical