Summary of LPL

LPL encodes for the enzyme lipoprotein lipase. It plays a role in breaking down fat in the form of triglycerides. When lipoprotein lipase breaks down triglycerides, the fat molecules are used by the body as energy or stored in fatty tissue for later use (R). 

Mutations in this can cause familial lipoprotein lipase deficiency, which will lead to an increase in fat and cause inflammation (R). 

The Function of LPL

The primary function of this lipase is the hydrolysis of triglycerides of circulating chylomicrons and very low density lipoproteins (VLDL). Binding to heparin sulfate proteogylcans at the cell surface is vital to the function. The apolipoprotein, APOC2, acts as a coactivator of LPL activity in the presence of lipids on the luminal surface of vascular endothelium.

Protein names

Recommended name:

Lipoprotein lipase

Short name:


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Top Gene-Substance Interactions

LPL Interacts with These Diseases

Substances That Increase LPL

Substances That Decrease LPL

Advanced Summary

Conditions with Increased Gene Activity

Conditions with Decreased Gene Activity