The Function of LIFR
Signal-transducing molecule. May have a common pathway with IL6ST. The soluble form inhibits the biological activity of LIF by blocking its binding to receptors on target cells.
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Protein names
Recommended name:
Leukemia inhibitory factor receptorShort name:
LIF-RAlternative name(s):
LIF receptorCD antigen CD118
Top Gene-Substance Interactions
LIFR Interacts with These Diseases
| Disease | Score |
Substances That Increase LIFR
| Substances | Interaction | Organism | Category |
Substances That Decrease LIFR
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Technical
The following transcription factors affect gene expression:
Gene Pathways:
Molecular Function:
- Leukemia Inhibitory Factor Receptor Activity
- Ciliary Neurotrophic Factor Receptor Binding
- Growth Factor Binding
Biological Processes:
- Cell Surface Receptor Signaling Pathway
- Positive Regulation Of Cell Proliferation
- Negative Regulation Of Muscle Cell Apoptotic Process
- Response To Organic Cyclic Compound
- Cytokine-Mediated Signaling Pathway
- Response To Cytokine
- Oncostatin-M-Mediated Signaling Pathway
- Neuron Projection Morphogenesis
- Leukemia Inhibitory Factor Signaling Pathway
- Ciliary Neurotrophic Factor-Mediated Signaling Pathway