Summary of LDLR

LDLR (low density lipoprotein receptor) is a protein coding gene. Low density lipoprotein is needed for the rate-limiting step in cholesterol synthesis and play a critical role in regulating the amount of cholesterol in the blood (R).

Mutations in the gene can cause high cholesterol (R). 

It's better to have this gene increased most of the time.
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The Function of LDLR

(Microbial infection) Acts as a receptor for hepatitis C virus in hepatocytes, but not through a direct interaction with viral proteins (PubMed:10535997, PubMed:12615904). Acts as a receptor for vesicular stomatitis virus (PubMed:23589850). In case of HIV-1 infection, may function as a receptor for extracellular Tat in neurons, mediating its internalization in uninfected cells (PubMed:11100124).

Protein names

Recommended name:

Low-density lipoprotein receptor

Alternative name(s):

LDL receptor

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Top Gene-Substance Interactions

LDLR Interacts with These Diseases

Substances That Increase LDLR

Substances That Decrease LDLR

Advanced Summary

Conditions with Increased Gene Activity

Conditions with Decreased Gene Activity