Summary of KRAS

The gene codes for a protein, KRAS proto-oncogene, GTPase. A single amino acid substitution causes mutation, which is implicated in several malignancies [R].

The Function of KRAS

Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. Plays an important role in the regulation of cell proliferation (PubMed:23698361, PubMed:22711838). Plays a role in promoting oncogenic events by inducing transcriptional silencing of tumor suppressor genes (TSGs) in colorectal cancer (CRC) cells in a ZNF304-dependent manner (PubMed:24623306).

Protein names

Recommended name:

GTPase KRas

Alternative name(s):

K-Ras 2

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Top Gene-Substance Interactions

KRAS Interacts with These Diseases

Substances That Increase KRAS

Substances That Decrease KRAS

Advanced Summary

Conditions with Increased Gene Activity

Conditions with Decreased Gene Activity