The Function of KLF15

Transcriptional regulator that binds to the GA element of the CLCNKA promoter. Binds to the KCNIP2 promoter and regulates KCNIP2 circadian expression in the heart (By similarity). Is a repressor of CTGF expression, involved in the control of cardiac fibrosis. It is also involved in the control of cardiac hypertrophy acting through the inhibition of MEF2A and GATA4 (By similarity). Involved in podocyte differentiation (By similarity). Inhibits MYOCD activity. Is a negative regulator of TP53 acetylation. Inhibits NF-kappa-B activation through repression of EP300-dependent RELA acetylation.

Protein names

Recommended name:

Krueppel-like factor 15

Alternative name(s):

Kidney-enriched krueppel-like factor

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Top Gene-Substance Interactions

KLF15 Interacts with These Diseases

Substances That Increase KLF15

Substances That Decrease KLF15

Conditions with Increased Gene Activity

Conditions with Decreased Gene Activity

Technical