The Function of JUP

Common junctional plaque protein. The membrane-associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. Acts as a substrate for VE-PTP and is required by it to stimulate VE-cadherin function in endothelial cells. Can replace beta-catenin in E-cadherin/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton.

Protein names

Recommended name:

Junction plakoglobin

Alternative name(s):

Catenin gamma
Desmoplakin III

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Top Gene-Substance Interactions

JUP Interacts with These Diseases

Substances That Increase JUP

Substances That Decrease JUP

Conditions with Increased Gene Activity

Conditions with Decreased Gene Activity