Summary of JUN

The gene codes for a protein, Jun proto-oncogene, AP-1 transcription factor subunit. It regulates gene expression [R].


The Function of JUN

Transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3'. Promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. Involved in activated KRAS-mediated transcriptional activation of USP28 in colorectal cancer (CRC) cells (PubMed:24623306). Binds to the USP28 promoter in colorectal cancer (CRC) cells (PubMed:24623306).

Protein names

Recommended name:

Transcription factor AP-1

Short name:

AP1

Alternative name(s):

Activator protein 1
Proto-oncogene c-Jun
V-jun avian sarcoma virus 17 oncogene homolog
p39

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Top Gene-Substance Interactions

JUN Interacts with These Diseases

Substances That Increase JUN

Substances That Decrease JUN

Conditions with Increased Gene Activity

Conditions with Decreased Gene Activity

Technical