Summary

The gene codes for a protein, Jun proto-oncogene, AP-1 transcription factor subunit. It regulates gene expression [R].


Function

Transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3'. Promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. Involved in activated KRAS-mediated transcriptional activation of USP28 in colorectal cancer (CRC) cells (PubMed:24623306). Binds to the USP28 promoter in colorectal cancer (CRC) cells (PubMed:24623306).

Get a Grip on Your Health. Use SelfDecode to Interpret your Genome Today! GET INSTANT ACCESS

Top Gene-Substance Interactions

Gene Interacts with Diseases

All Ways to Increase Gene

All Ways to Decrease Gene

Conditions with Increased Gene Activity

Conditions with Decreased Gene Activity

Technical