Summary

The gene codes for a protein, jumonji domain containing 1C. Mutations are linked to Rett syndrome and intellectual disability [R].


Function

Probable histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May be involved in hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target genes.

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