Function

Intracellular channel that mediates calcium release from the endoplasmic reticulum following stimulation by inositol 1,4,5-trisphosphate. Involved in the regulation of epithelial secretion of electrolytes and fluid through the interaction with AHCYL1 (By similarity). Plays a role in ER stress-induced apoptosis. Cytoplasmic calcium released from the ER triggers apoptosis by the activation of CaM kinase II, eventually leading to the activation of downstream apoptosis pathways.

Protein names

Recommended name:

Inositol 1,4,5-trisphosphate receptor type 1

Short name:

IP3R 1

Alternative name(s):

IP3 receptor isoform 1
InsP3R1
Type 1 inositol 1,4,5-trisphosphate receptor
Type 1 InsP3 receptor

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