The Function of IRF2

Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)) and represses those genes. Also acts as an activator for several genes including H4 and IL7. Constitutively binds to the ISRE promoter to activate IL7. Involved in cell cycle regulation through binding the site II (HiNF-M) promoter region of H4 and activating transcription during cell growth. Antagonizes IRF1 transcriptional activation.

Protein names

Recommended name:

Interferon regulatory factor 2

Short name:

IRF-2

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Top Gene-Substance Interactions

IRF2 Interacts with These Diseases

Substances That Increase IRF2

Substances That Decrease IRF2

Conditions with Increased Gene Activity

Conditions with Decreased Gene Activity

Technical