The Function of IRF1
Transcriptional regulator which displays a remarkable functional diversity in the regulation of cellular responses. These include the regulation of IFN and IFN-inducible genes, host response to viral and bacterial infections, regulation of many genes expressed during hematopoiesis, inflammation, immune responses and cell proliferation and differentiation, regulation of the cell cycle and induction of growth arrest and programmed cell death following DNA damage. Stimulates both innate and acquired immune responses through the activation of specific target genes and can act as a transcriptional activator and repressor regulating target genes by binding to an interferon-stimulated response element (ISRE) in their promoters. Its target genes for transcriptional activation activity include: genes involved in anti-viral response, such as IFN-alpha/beta, DDX58/RIG-I, TNFSF10/TRAIL, OAS1/2, PIAS1/GBP, EIF2AK2/PKR and RSAD2/viperin; antibacterial response, such as NOS2/INOS; anti-proliferative response, such as p53/TP53, LOX and CDKN1A; apoptosis, such as BBC3/PUMA, CASP1, CASP7 and CASP8; immune response, such as IL7, IL12A/B and IL15, PTGS2/COX2 and CYBB; DNA damage responses and DNA repair, such as POLQ/POLH; MHC class I expression, such as TAP1, PSMB9/LMP2, PSME1/PA28A, PSME2/PA28B and B2M and MHC class II expression, such as CIITA. Represses genes involved in anti-proliferative response, such as BIRC5/survivin, CCNB1, CCNE1, CDK1, CDK2 and CDK4 and in immune response, such as FOXP3, IL4, ANXA2 and TLR4. Stimulates p53/TP53-dependent transcription through enhanced recruitment of EP300 leading to increased acetylation of p53/TP53. Plays an important role in immune response directly affecting NK maturation and activity, macrophage production of IL12, Th1 development and maturation of CD8+ T-cells. Also implicated in the differentiation and maturation of dendritic cells and in the suppression of regulatory T (Treg) cells development. Acts as a tumor suppressor and plays a role not only in antagonism of tumor cell growth but also in stimulating an immune response against tumor cells.
Protein names
Recommended name:
Interferon regulatory factor 1Short name:
IRF-1- RS13164856 (IRF1) ??
- RS2070729 (IRF1) ??
- RS2549003 (IRF1) ??
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Top Gene-Substance Interactions
IRF1 Interacts with These Diseases
Disease | Score |
Substances That Increase IRF1
Substances | Interaction | Organism | Category |
Substances That Decrease IRF1
Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Gene Pathways:
Induction:
By viruses and interferon (IFN).
Enzyme Regulation:
Activated by MYD88.
Molecular Function:
- Rna Polymerase Ii Core Promoter Proximal Region Sequence-Specific Dna Binding
- Transcriptional Activator Activity, Rna Polymerase Ii Core Promoter Proximal Region Sequence-Specific Binding
- Dna Binding
Biological Processes:
- Regulation Of Adaptive Immune Response
- Transcription From Rna Polymerase Ii Promoter
- Apoptotic Process
- Cell Cycle Arrest
- Blood Coagulation
- Negative Regulation Of Cell Proliferation
- Positive Regulation Of Type I Interferon Production
- Positive Regulation Of Interferon-Beta Production
- Regulation Of Myd88-Dependent Toll-Like Receptor Signaling Pathway
- Cellular Response To Interferon-Beta
- Cd8-Positive, Alpha-Beta T Cell Differentiation
- Positive Regulation Of Interleukin-12 Biosynthetic Process
- Regulation Of Innate Immune Response
- Negative Regulation Of Regulatory T Cell Differentiation
- Negative Regulation Of Transcription, Dna-Templated
- Positive Regulation Of Transcription, Dna-Templated
- Positive Regulation Of Transcription From Rna Polymerase Ii Promoter
- Defense Response To Virus
- Regulation Of Cell Cycle
- Interferon-Gamma-Mediated Signaling Pathway
- Type I Interferon Signaling Pathway
- Cellular Response To Mechanical Stimulus
- Regulation Of Cd8-Positive, Alpha-Beta T Cell Proliferation