Summary of IL6R
IL-6R is the receptor protein for IL-6. It creates a cellular signal based off of IL-6 levels in the bloodstream. Because of this, the receptor protein plays a large role in inflammatory response. Dysregulation of IL-6R occurs in many diseases such as cancers and autoimmune diseases.
The Function of IL6R
Low concentration of a soluble form of IL6 receptor acts as an agonist of IL6 activity.
Protein names
Recommended name:
Interleukin-6 receptor subunit alphaAlternative name(s):
IL-6 receptor subunit alphaIL-6R subunit alpha
IL-6R-alpha
IL-6RA
IL-6R 1
Membrane glycoprotein 80
gp80
CD antigen CD126
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- RS12118721 (IL6R) ??
- RS2228145 (IL6R) ??
- RS2229238 (IL6R) ??
- RS4129267 (IL6R) ??
- RS4537545 (IL6R) ??
- RS4845617 (IL6R) ??
- RS4845618 (IL6R) ??
- RS4845625 (IL6R) ??
- RS61812598 (IL6R) ??
- RS6684439 (IL6R) ??
- RS6689306 (IL6R) ??
- RS7529229 (IL6R) ??
- RS8192282 (IL6R) ??
- RS8192284 (IL6R) ??
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Top Gene-Substance Interactions
IL6R Interacts with These Diseases
| Disease | Score |
Substances That Increase IL6R
| Substances | Interaction | Organism | Category |
Substances That Decrease IL6R
| Substances | Interaction | Organism | Category |
Advanced Summary
Covered on Genetics Home Reference: rheumatoid arthritisFrom NCBI Gene: Serum level of interleukin 6Serum level of interleukin-6 soluble receptor
From NCBI Gene: This gene encodes a subunit of the interleukin 6 (IL6) receptor complex. Interleukin 6 is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in the immune response. The IL6 receptor is a protein complex consisting of this protein and interleukin 6 signal transducer (IL6ST/GP130/IL6-beta), a receptor subunit also shared by many other cytokines. Dysregulated production of IL6 and this receptor are implicated in the pathogenesis of many diseases, such as multiple myeloma, autoimmune diseases and prostate cancer. Alternatively spliced transcript variants encoding distinct isoforms have been reported. A pseudogene of this gene is found on chromosome 9.[provided by RefSeq, May 2011] From UniProt: Low concentration of a soluble form of IL6 receptor acts as an agonist of IL6 activity. Part of the receptor for interleukin 6. Binds to IL6 with low affinity, but does not transduce a signal. Signal activation necessitate an association with IL6ST. Activation may lead to the regulation of the immune response, acute-phase reactions and hematopoiesis.
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Isoform 2 is expressed in peripheral blood mononuclear cells and weakly found in urine and serum.
Gene Pathways:
Molecular Function:
- Interleukin-6 Receptor Activity
- Enzyme Binding
- Interleukin-6 Binding
- Protein Homodimerization Activity
- Ciliary Neurotrophic Factor Binding
Biological Processes:
- Hepatic Immune Response
- Neutrophil Mediated Immunity
- Monocyte Chemotaxis
- Positive Regulation Of Leukocyte Chemotaxis
- Acute-Phase Response
- Positive Regulation Of Cell Proliferation
- Positive Regulation Of Activation Of Janus Kinase Activity
- Cytokine-Mediated Signaling Pathway
- Endocrine Pancreas Development
- Negative Regulation Of Interleukin-8 Production
- Positive Regulation Of Chemokine Production
- Positive Regulation Of Interleukin-6 Production
- Negative Regulation Of Collagen Biosynthetic Process
- Response To Cytokine
- Positive Regulation Of Tyrosine Phosphorylation Of Stat3 Protein
- Positive Regulation Of Mapk Cascade
- Positive Regulation Of Osteoblast Differentiation
- Positive Regulation Of Smooth Muscle Cell Proliferation
- Positive Regulation Of Peptidyl-Tyrosine Phosphorylation
- Defense Response To Gram-Negative Bacterium
- Defense Response To Gram-Positive Bacterium
- Interleukin-6-Mediated Signaling Pathway
- Ciliary Neurotrophic Factor-Mediated Signaling Pathway
- Extrinsic Apoptotic Signaling Pathway
Drug Bank:
- Tocilizumab