Summary of IL6

Interleukin-6 (IL-6) is a cytokine with well-defined pro- and anti-inflammatory properties (R). It regulates the immune system and plays a role in cognitive function. IL-6 can activate cells in two ways:  One way is anti-inflammatory and helps in tissue regeneration. Another is pro-inflammatory and causes all kinds of problems. IL-6 levels are increased in nearly all disease states (R).

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The Function of IL6

Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasmacytoma growth and induces nerve cells differentiation.

Protein names

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Alternative name(s):

B-cell stimulatory factor 2
CTL differentiation factor
Hybridoma growth factor
Interferon beta-2

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Top Gene-Substance Interactions

IL6 Interacts with These Diseases


Substances That Increase IL6

Substances That Decrease IL6

Advanced Summary

Conditions with Increased Gene Activity

Conditions with Decreased Gene Activity