Summary of IL4

IL4 (interleukin 4) encodes a protein that helps regulate the immune system (R). 

IL4 stimulates the Th2 arm of the immune system.

The Function of IL4

Participates in at least several B-cell activation processes as well as of other cell types (PubMed:3016727). It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages.

Protein names

Recommended name:


Short name:


Alternative name(s):

B-cell stimulatory factor 1
Lymphocyte stimulatory factor 1

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Top Gene-Substance Interactions

IL4 Interacts with These Diseases

Substances That Increase IL4

Substances That Decrease IL4

Advanced Summary

Conditions with Increased Gene Activity

Conditions with Decreased Gene Activity