Summary of IL1RN

This gene encodes a protein that modifies a variety of interleukin 1 related immune and inflammatory responses. It is associated with higher risk for bone fractures and gastric cancer (R). 


The Function of IL1RN

Inhibits the activity of interleukin-1 by binding to receptor IL1R1 and preventing its association with the coreceptor IL1RAP for signaling. Has no interleukin-1 like activity. Binds functional interleukin-1 receptor IL1R1 with greater affinity than decoy receptor IL1R2; however, the physiological relevance of the latter association is unsure.

Protein names

Recommended name:

Interleukin-1 receptor antagonist protein

Short name:

IRAP

Alternative name(s):

IL-1RN
IL-1ra
ICIL-1RA
IL1 inhibitor
Anakinra

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Top Gene-Substance Interactions

IL1RN Interacts with These Diseases

Substances That Increase IL1RN

Substances That Decrease IL1RN

Advanced Summary

Conditions with Increased Gene Activity

Conditions with Decreased Gene Activity

Technical