Immune cells produce and release IL-1b and TNF (R). Both are usually elevated together because each increases the other (RR2), so it's hard to tease out what plays a more significant role. TNF makes IL-1b active (R) and IL-1b also increases TNF inflammation (R), making the two synergistically harmful  IL-1 has two main forms: IL-1beta and IL-1alpha.

 IL-1beta seems to be the most significant in relation to disease and there's more research on it because it possesses a strong pro-inflammatory effect. 

IL-1b is part of the mechanism of inducing sleep and increases non-rem sleep and the time it takes to fall asleep (R, R2). Therefore, this is not something you want to inhibit during the night.

It's better to have this gene decreased most of the time.


Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B-cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells.

Protein names

Recommended name:

Interleukin-1 beta

Alternative name(s):

IL-1 beta

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