Summary of IL1B

Immune cells produce and release IL-1b and TNF (R). Both are usually elevated together because each increases the other (RR2), so it's hard to tease out what plays a more significant role. TNF makes IL-1b active (R) and IL-1b also increases TNF inflammation (R), making the two synergistically harmful  IL-1 has two main forms: IL-1beta and IL-1alpha.

 IL-1beta seems to be the most significant in relation to disease and there's more research on it because it possesses a strong pro-inflammatory effect. 

IL-1b is part of the mechanism of inducing sleep and increases non-rem sleep and the time it takes to fall asleep (R, R2). Therefore, this is not something you want to inhibit during the night.


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The Function of IL1B

Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B-cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells.

Protein names

Recommended name:

Interleukin-1 beta

Alternative name(s):

IL-1 beta
Catabolin

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Top Gene-Substance Interactions

IL1B Interacts with These Diseases

Fixes

Substances That Increase IL1B

Substances That Decrease IL1B

Advanced Summary

Conditions with Increased Gene Activity

Conditions with Decreased Gene Activity

Technical