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  1. Home
  2. Genes
  3. IL15

IL15 (Interleukin 15)

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Summary of IL15

The gene codes for a protein, interleukin 15. It regulates T and natural killer cell activation and proliferation [R].

The Function of IL15

Cytokine that stimulates the proliferation of T-lymphocytes. Stimulation by IL-15 requires interaction of IL-15 with components of IL-2R, including IL-2R beta and probably IL-2R gamma but not IL-2R alpha.

Protein names

Recommended name:

Interleukin-15

Short name:

IL-15

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IL15 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS10519612 (IL15) ??
  2. RS10519613 (IL15) ??
  3. RS10833 (IL15) ??
  4. RS17007695 (IL15) ??

Top Gene-Substance Interactions

IL15 Interacts with These Diseases

Disease Score

Substances That Increase IL15

Substances Interaction Organism Category

Substances That Decrease IL15

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • NF-kappaB
  • NF-kappaB1
  • IRF-1
  • STAT5A
  • FOXO3
  • FOXO3a
  • STAT3
  • c-Rel
  • GR
  • GR-alpha

Tissue specificity:

Most abundant in placenta and skeletal muscle. It is also detected in the heart, lung, liver and kidney. IL15-S21AA is preferentially expressed in tissues such as testis and thymus.

Gene Pathways:

  • Intestinal immune network for IgA production
  • Rheumatoid arthritis
  • Jak-STAT signaling pathway
  • Cytokine-cytokine receptor interaction

Molecular Function:

  • Cytokine Activity

Biological Processes:

  • Natural Killer Cell Differentiation
  • Nk T Cell Proliferation
  • Inflammatory Response
  • Immune Response
  • Signal Transduction
  • Cell-Cell Signaling
  • Aging
  • Positive Regulation Of Cell Proliferation
  • Skeletal Muscle Atrophy
  • Hyaluronan Metabolic Process
  • Positive Regulation Of Interleukin-17 Production
  • Positive Regulation Of Natural Killer Cell Proliferation
  • Positive Regulation Of Natural Killer Cell Differentiation
  • Positive Regulation Of Tissue Remodeling
  • Positive Regulation Of T Cell Proliferation
  • Tyrosine Phosphorylation Of Stat5 Protein
  • Positive Regulation Of Tyrosine Phosphorylation Of Stat3 Protein
  • Extrathymic T Cell Selection
  • Regulation Of T Cell Differentiation
  • Cell Maturation
  • Lymph Node Development
  • Negative Regulation Of Smooth Muscle Cell Proliferation
  • Regulation Of Defense Response To Virus By Host
  • Positive Regulation Of Inflammatory Response
  • Positive Regulation Of Immune Response
  • Cellular Response To Vitamin D
  • Positive Regulation Of Protein O-Linked Glycosylation
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| A306_10360| Anapl_18876| AS27_01276| AS28_13054| CB1_002231012| H920_12052| IL-15| interleukin-15| interleukin-15 variant 2| M91_05668| M959_05130| MDA_GLEAN10017178| N300_03044| N301_04947| N302_10893| N303_06625| N305_10652| N306_08474| N308_06541| N309_13602| N310_00521| N312_10651| N320_03396| N321_07396| N322_13584| N324_10729| N325_12824| N326_01983| N327_05323| N329_02537| N330_13391| N331_02303| N332_04576| N333_02994| N334_05788| N335_10511| N336_03166| N339_07201| N340_04413| N341_01880| PAL_GLEAN10016546| PANDA_013356| UY3_14636| Y1Q_009024| Y956_01803| Z169_05705| il15
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