Summary of IGFBP3

IGFBP3 (insulin like growth factor binding protein 3) encodes a protein that forms a complex with insulin-like growth factor acid-labile subunit (IGFALS) and either insulin-like growth factor 1 or 2 (R). 

Polymorphisms of this can cause cancer (R). 

The Function of IGFBP3

IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Also exhibits IGF-independent antiproliferative and apoptotic effects mediated by its receptor TMEM219/IGFBP-3R.

Protein names

Recommended name:

Insulin-like growth factor-binding protein 3

Short name:


Alternative name(s):

IGF-binding protein 3

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Top Gene-Substance Interactions

IGFBP3 Interacts with These Diseases

Substances That Increase IGFBP3

Substances That Decrease IGFBP3

Advanced Summary

Conditions with Increased Gene Activity

Conditions with Decreased Gene Activity