Summary of IGF1R

IGF1R encodes for insulin growth factor receptors; overexpression can stop cell death by enhancing cell survival and is present in malignant tissues (R). 


The Function of IGF1R

When present in a hybrid receptor with INSR, binds IGF1. PubMed:12138094 shows that hybrid receptors composed of IGF1R and INSR isoform Long are activated with a high affinity by IGF1, with low affinity by IGF2 and not significantly activated by insulin, and that hybrid receptors composed of IGF1R and INSR isoform Short are activated by IGF1, IGF2 and insulin. In contrast, PubMed:16831875 shows that hybrid receptors composed of IGF1R and INSR isoform Long and hybrid receptors composed of IGF1R and INSR isoform Short have similar binding characteristics, both bind IGF1 and have a low affinity for insulin.

Protein names

Recommended name:

Insulin-like growth factor 1 receptor

Alternative name(s):

Insulin-like growth factor I receptor
IGF-I receptor
CD antigen CD221

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Top Gene-Substance Interactions

IGF1R Interacts with These Diseases

Fixes

Substances That Increase IGF1R

Substances That Decrease IGF1R

Advanced Summary

Conditions with Increased Gene Activity

Conditions with Decreased Gene Activity

Technical