Summary of IFNG

This gene encodes a protein that helps trigger a response to infections.  Interferon-gamma is a Th1 driven inflammatory cytokine.

Mutations in this gene are associated with an increased susceptibility to infections and autoimmune diseases (R). 


Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.

Protein names

Recommended name:

Interferon gamma

Alternative name(s):

Immune interferon

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Top Gene-Substance Interactions

IFNG Interacts with These Diseases

Substances That Increase IFNG

Substances That Decrease IFNG

Advanced Summary

Conditions with Increased Gene Activity

Conditions with Decreased Gene Activity