Summary

This gene encodes a protein that helps trigger a response to infections.  Interferon-gamma is a Th1 driven inflammatory cytokine.

Mutations in this gene are associated with an increased susceptibility to infections and autoimmune diseases (R). 


Function

Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.

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