Summary of HTR3B

5-HT3B are expressed in several brain regions, including the amygdala, caudate, and hippocampus (R).

The 5-HT3R might have a significant role in regulating reward (R).

Genetic variation within HTR3B has been shown to influence vulnerability to bipolar disorder (R) and major depression (R). The 5-HT3 receptor might be a causal factor in alcoholism (R).

The Function of HTR3B

This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses. It is a cation-specific, but otherwise relatively nonselective, ion channel.

Protein names

Recommended name:

5-hydroxytryptamine receptor 3B

Short name:


Alternative name(s):

Serotonin receptor 3B

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Top Gene-Substance Interactions

HTR3B Interacts with These Diseases

Substances That Increase HTR3B

Substances That Decrease HTR3B

Advanced Summary

Conditions with Increased Gene Activity

Conditions with Decreased Gene Activity