The Function of HSPB1
Involved in stress resistance and actin organization.
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Protein names
Recommended name:
Heat shock protein beta-1Alternative name(s):
HspB128 kDa heat shock protein
Estrogen-regulated 24 kDa protein
Heat shock 27 kDa protein
HSP 27
Stress-responsive protein 27
SRP27
- RS2908197 (HSPB1) ??
- RS758944 (HSPB1) ??
- RS7789940 (HSPB1) ??
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Top Gene-Substance Interactions
HSPB1 Interacts with These Diseases
| Disease | Score |
Substances That Increase HSPB1
| Substances | Interaction | Organism | Category |
Substances That Decrease HSPB1
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Technical
The following transcription factors affect gene expression:
Tissue specificity:
Detected in all tissues tested: skeletal muscle, heart, aorta, large intestine, small intestine, stomach, esophagus, bladder, adrenal gland, thyroid, pancreas, testis, adipose tissue, kidney, liver, spleen, cerebral cortex, blood serum and cerebrospinal fluid. Highest levels are found in the heart and in tissues composed of striated and smooth muscle.
Gene Pathways:
Induction:
Expressed in response to environmental stresses such as heat shock, or estrogen stimulation in MCF-7 cells. Up-regulated in response to enterovirus 71 (EV71) infection (at protein level).
Molecular Function:
- Protein Kinase C Binding
- Protein Kinase C Inhibitor Activity
- Protein Kinase Binding
- Identical Protein Binding
- Ubiquitin Binding
- Poly(A) Rna Binding
Biological Processes:
- Retina Homeostasis
- Regulation Of Translational Initiation
- Negative Regulation Of Protein Kinase Activity
- Movement Of Cell Or Subcellular Component
- Response To Unfolded Protein
- Response To Virus
- Regulation Of Autophagy
- Positive Regulation Of Interleukin-1 Beta Production
- Intracellular Signal Transduction
- Cellular Response To Vascular Endothelial Growth Factor Stimulus
- Positive Regulation Of Endothelial Cell Chemotaxis By Vegf-Activated Vascular Endothelial Growth Factor Receptor Signaling Pathway
- Positive Regulation Of Tumor Necrosis Factor Biosynthetic Process
- Negative Regulation Of Apoptotic Process
- Regulation Of I-Kappab Kinase/Nf-Kappab Signaling
- Regulation Of Mrna Stability
- Positive Regulation Of Blood Vessel Endothelial Cell Migration
- Positive Regulation Of Angiogenesis
- Vascular Endothelial Growth Factor Receptor Signaling Pathway
- Platelet Aggregation
- Negative Regulation Of Oxidative Stress-Induced Intrinsic Apoptotic Signaling Pathway
- Positive Regulation Of Endothelial Cell Chemotaxis