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  1. Home
  2. Genes
  3. HSPB1

HSPB1 (Heat shock protein family B (small) member 1)

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The Function of HSPB1

Involved in stress resistance and actin organization.

Protein names

Recommended name:

Heat shock protein beta-1

Alternative name(s):

HspB1
28 kDa heat shock protein
Estrogen-regulated 24 kDa protein
Heat shock 27 kDa protein
HSP 27
Stress-responsive protein 27
SRP27

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HSPB1 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS2908197 (HSPB1) ??
  2. RS758944 (HSPB1) ??
  3. RS7789940 (HSPB1) ??

Top Gene-Substance Interactions

HSPB1 Interacts with These Diseases

Disease Score

Substances That Increase HSPB1

Substances Interaction Organism Category

Substances That Decrease HSPB1

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

Tissue specificity:

Detected in all tissues tested: skeletal muscle, heart, aorta, large intestine, small intestine, stomach, esophagus, bladder, adrenal gland, thyroid, pancreas, testis, adipose tissue, kidney, liver, spleen, cerebral cortex, blood serum and cerebrospinal fluid. Highest levels are found in the heart and in tissues composed of striated and smooth muscle.

Gene Pathways:

  • Amoebiasis
  • Gene Expression
  • MAPK signaling pathway
  • Metabolism of RNA
  • Signal Transduction
  • VEGF signaling pathway

Induction:

Expressed in response to environmental stresses such as heat shock, or estrogen stimulation in MCF-7 cells. Up-regulated in response to enterovirus 71 (EV71) infection (at protein level).

Molecular Function:

  • Protein Kinase C Binding
  • Protein Kinase C Inhibitor Activity
  • Protein Kinase Binding
  • Identical Protein Binding
  • Ubiquitin Binding
  • Poly(A) Rna Binding

Biological Processes:

  • Retina Homeostasis
  • Regulation Of Translational Initiation
  • Negative Regulation Of Protein Kinase Activity
  • Movement Of Cell Or Subcellular Component
  • Response To Unfolded Protein
  • Response To Virus
  • Regulation Of Autophagy
  • Positive Regulation Of Interleukin-1 Beta Production
  • Intracellular Signal Transduction
  • Cellular Response To Vascular Endothelial Growth Factor Stimulus
  • Positive Regulation Of Endothelial Cell Chemotaxis By Vegf-Activated Vascular Endothelial Growth Factor Receptor Signaling Pathway
  • Positive Regulation Of Tumor Necrosis Factor Biosynthetic Process
  • Negative Regulation Of Apoptotic Process
  • Regulation Of I-Kappab Kinase/Nf-Kappab Signaling
  • Regulation Of Mrna Stability
  • Positive Regulation Of Blood Vessel Endothelial Cell Migration
  • Positive Regulation Of Angiogenesis
  • Vascular Endothelial Growth Factor Receptor Signaling Pathway
  • Platelet Aggregation
  • Negative Regulation Of Oxidative Stress-Induced Intrinsic Apoptotic Signaling Pathway
  • Positive Regulation Of Endothelial Cell Chemotaxis
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| Hsp25| 25 kDa heat shock protein| 25 kDa IAP| 27kDa| 28 kDa heat shock protein| actin polymerization inhibitor| CB1_000518036| cmt2f| D623_10015232| epididymis secretory protein Li 102| estrogen-regulated 24 kDa protein| growth-related 25 kDa protein| H920_03108| heat shock 25 kDa protein| heat shock 27 kDa protein| heat shock 27 kDa protein 1| heat shock 27kDa protein 1| heat shock 27kD protein 1| heat shock protein 1| heat shock protein, 25 kDa| heat shock protein 27| heat shock protein 27 kDa beta-1| heat shock protein, alpha-crystallin-related, 1| heat shock protein B1| Heat shock protein beta-1| heat shock protein family B member 1| heat shock protein family B member 1 variant 1| heat shock protein family B member 1 variant 2| heat shock protein HSP27-like protein| HEL-S-102| HMN2B| hs.76067| hsp1| HSP 25| Hsp27| HSP 27| Hsp27alpha| hsp28| I79_007264| inhibitor of actin polymerization| low molecular weight heat shock protein 27| M91_01041| M959_10961| N300_03451| N303_12088| p25| PAL_GLEAN10012025| PANDA_012655| SRP27| stress-responsive protein 27| TREES_T100020790| truncated hsp25| UY3_14010| Y1Q_013734| Z169_00588| hspb1
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