Summary of HSPA5

The gene codes for a protein, heat shock protein family A (Hsp70) member 5. It plays a role in monitoring protein transport through the cell [R].


The Function of HSPA5

Probably plays a role in facilitating the assembly of multimeric protein complexes inside the endoplasmic reticulum. Involved in the correct folding of proteins and degradation of misfolded proteins via its interaction with DNAJC10, probably to facilitate the release of DNAJC10 from its substrate.

Protein names

Recommended name:

78 kDa glucose-regulated protein

Alternative name(s):

GRP-78
Endoplasmic reticulum lumenal Ca(2+
Heat shock 70 kDa protein 5
Immunoglobulin heavy chain-binding protein
BiP

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Top Gene-Substance Interactions

HSPA5 Interacts with These Diseases

Substances That Increase HSPA5

Substances That Decrease HSPA5

Advanced Summary

Conditions with Increased Gene Activity

Conditions with Decreased Gene Activity

Technical