Summary of HSD17B4

The gene codes for a protein, hydroxysteroid 17-beta dehydrogenase 4. Defects are caused by D-bifunctional protein deficiency (DBPD). A pseudogene is on chromosome 8 [R].

The Function of HSD17B4

Bifunctional enzyme acting on the peroxisomal beta-oxidation pathway for fatty acids. Catalyzes the formation of 3-ketoacyl-CoA intermediates from both straight-chain and 2-methyl-branched-chain fatty acids.

Protein names

Recommended name:

Peroxisomal multifunctional enzyme type 2

Short name:


Alternative name(s):

17-beta-hydroxysteroid dehydrogenase 4
17-beta-HSD 4
D-bifunctional protein
Multifunctional protein 2
Short chain dehydrogenase/reductase family 8C member 1
3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholest-24-enoyl-CoA hydratase

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Top Gene-Substance Interactions

HSD17B4 Interacts with These Diseases

Substances That Increase HSD17B4

Substances That Decrease HSD17B4

Advanced Summary

Conditions with Increased Gene Activity

Conditions with Decreased Gene Activity